SYDNEY SIMS

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FIRST DAY OF 7TH GRADE!!!!!


January 15,2004
Diagnosis  Neuroblastoma stage 4

January 20  May 2004  All Childrens Hospital, FL
4 high dose rounds of Cyclophosphamide, Doxorubicin, & Vincristine Chemotherapy
2 high dose rounds of Cisplatin & Etoposide Chemotherapy
Stem cell harvest

July 2, 2004  Memorial Sloan Kettering Cancer Center NY
Surgery  tumor resection, left adrenal gland, and lymph nodes

July 19,2004  MSKCC
1 high dose round of Cyclophosphamide, Topotecan, & Vincristine Chemo

September 2, 2004   MSKCC
Radiation to left femur  10 treatments
1 high dose round of Cyclophosphamide & Irinotecan Chemo

October 2004  MSKCC
***1st clean Bone Marrow biopsies (No Evidence of Disease)***
Only disease located in left femur
Began round 1 of 3f8 antibody treatment/GMCSF followed by Accutane

November 2004  MSKCC
Round 2 of 3f8/GMCSF followed by Accutane
Acquired HAMA (Human Anti-Mouse Antibody)
Successful Stem Cell harvest
Radiation to Skull 10 treatments
Radiation to Orbits 10 treatments
Radiation to Abdomin 10 treatments

February 21, 2005  MSKCC
Round 3 of 3f8/GMCSF
(Stopped treatment 3 days into it due to allergic reaction)
Continued on Accutane
Acquired HAMA again

April 17 2005  MSKCC
Completed round 5 of Accutane, stopped treatments  toxic

April 19,2005  MSKCC
Disease ***RELAPSE*** in Bone Marrow

April 25,2005 MSKCC
1 high dose round of Cyclophosphamide, Irinotecan, & Vincristine Chemo

May 31,2005  MSKCC
1 high dose round of Cyclophosphamide, Irinotecan, & Vincristine Chemo

June 2005  MSKCC
*** Bone Marrows   NED *****
Persistant spot in left femur
Began Low Dose Temodar Chemotherapy, Thalidomide, & celebrex (T.T.C.)
Completed 6 cycles

February 2006  MSKCC
MIBG scan results  Spot in Femur Appears to have intensified

March 16,2006  MSKCC
Radiation  (2nd time) Femur 7 high dose treatments

March 20,2006 MSKCC
1 high dose round of Irinotecan chemotherapy followed by
2 cycles of low dose T.T.C.

June 2006  All Childrens
Stopped Temodar chemo, (low blood counts)
Continued Thalidomide, Celebrex

September 25, 2006  MSKCC
Began round 1 of 3f8 antibody/ Beta Glucan

October 31, 2006  MSKCC
Round 2 of 3f8/beta glucan

December 5, 2006  MSKCC
Round 3 of 3f8/beta glucan  cut short 1 week due to HAMA

December 18,2006
Round 1 of Accutane

Jan 15, 2007
Round 2 of Accutane

February 12,2007
Round 3, 4, & 5 of Accutane, still HAMA
Disease remains in Femur  stable


May 2007
RELAPSE - SYdney has a new tumor on her aeorta behind her heart


June 2007
Surgery to remove new tumor, Chemotherapy - 5 rounds so far of Irinotecan/Temodar
Radiation - 10 "hits" to new tumor bed



December 2007
1/2 round (1 week) of Heat induced, High Dose 3F8 antibodies (12 Xs the strength of previous 3f8) Acquired HAMA after first week


January 2008
1 round low dose Temodar chemotherapy - marrow was too weak for it - took 6 weeks to recover, stopped chemo again

February 2008
Started Accutane for the 3rd time

APRIL 2008
Started Thalidomide and Celebrex again - completed 4 cycles

JULY 2008
Scans show stress fractures in Left Knee and left Tibia bones. All other disease - stable

AUGUST 2008
Starts 5th cycle of Celebrex and Thalidomide. Disease is stable in left femur - possible new spot in right hip (questionable)

SEPTEMBER 2008
Cycle 6 of Thalidomide?Celebrex>


OCTOBER 2008
High -Dose 3f8 - one round (12x's the normal dose)


This is a summary of Sydneys cancer treatments ONLY.  It does not include the countless number of Blood Transfusions, CT scans, MIBG scans, Bone Marrow biopsies and surgical procedures, GCSF shots, antibiotics for infections, and many, many hospital stays.  She has been through A LOT, and she is go
ing to BEAT THIS CANCER!!!


Please sign the guestbook, so Sydney will know who is checking in on her!! We love to hear from everyone!!








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If you would like to make a donation to help the family with all of the extra expenses and suppliment the loss of income, a fund has been set up for that purpose.  It is called the Sydney Sims Family Fund.  Rhonda Spradlin, the trustee, set up the fund, and handles all of the transactions at Bank of America.  The fund helps the family pay some of their monthly bills, along with plane tickets and other expenses incurred during travel.  Checks can be made out to....Sims Family Fund and mailed to...  Trustee @ 2817 Durant Trails Blvd.   Dover, FL 33527
Thank You










Sydlets are bracelets, necklaces, and ear rings made by Sydney and her mom. They are made with Swarovski crystal beads complimented with a sterling silver awareness ribbon, so they can be worn proudly, and spread the word on pediatric cancer, and the brave warrior children, like Sydney, who fight everyday for their lives.























Check out the new Marathon line of Sydlets!!!

Journal

Wednesday, November 12, 2008 8:59 AM CST

Hello,

We got SYdney's HAMA results last night, and unfortunately, she is HAMA positive. We were pretty-much expecting it, but were hoping that she would be negative. Last year, when she was HAMA positive, her HAMA # was around 5000 and it took 6 months for it to go down. Right now, her HAMA # is around 19,000, so we are not expecting it to go down for around a year. This is not a good place to be in because she can not do any (mouse)antibody therapy until the hama goes away.
So, what now???? Well, due to her blood counts still being very low, she is also not able to do any therapy such as chemotherapy, or anything having to do with radiation because it would lower her bloods counts further, and compromise her immune system more than it already is.
Luckily for us, Sydney's cancer is stable, and not progressive, so we can get away (right now) with a maitenance, low dose therapy.
She will be starting back on good ol' Thalidomide and Celebrex later this week. It is possible that she could be on this therapy for a year, or until something new is invented for Neuroblastoma.
I am ok with this treatment. It increases her appetite, and she needs to put on a few lbs. Over the past 2 months, SYd has lost 7 lbs, and she needs to put it back on. The thalidomide causes extreme sleepiness, so we will have an issue with that, especially since her extra curricular schedule has become so busy. Oh well, it is what it is.....
We will be back in NY December 10-13 for scans again. Hopefully, she will remain stable and we can continue as things are now.

Sydney and Drew are being inducted into the Junior National Honor Society on Monday. They are both really doing fantastic in school. Sydney also has an honor choir concert on Tuesday night, and the first BB game is coming up where she will be cheering. Busy, Busy, Busy, we are around here.

Thanks for checking in, and I'll will update again soon, Michelle

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Hospital Information:

Patient Room: 706

(Home) or Ronald Mc Donald House
(4105 Jade Lane) or 405 E. 73rd Street-room 511
(Valrico, Fl 33594) or New York, NY 10021
(Cell #813-310-5485) or 212-639-0100

Links:

E-mail Author: kasmic1@yahoo.com